藥品快速檢測技術研究與應用（英文版）

定　價：￥298.00

作　者：	金少鴻著
出版社：	化學工業(yè)出版社有限公司
叢編項：
標　簽：	暫缺

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京東 (￥298.00)

ISBN：	9787122338532	出版時間：	2019-06-01	包裝：	精裝
開本：	16開	頁數：		字數：

內容簡介

　　《藥品快速檢測技術的研究與應用（英文版）》為國家十三五重點出版物，對化學藥品的快速檢測理論與方法進行了詳細的闡述，收錄了化學藥品近紅外快速分析技術和HPLC的快速檢測方法。本書由部門編寫，內容原創(chuàng)。適用于從事藥物質量監(jiān)督與管理的人員。

作者簡介

　　金少鴻，中國食品藥品檢定研究院，前副所長、研究員。從事化學藥品檢定工作30多年，是我國藥品檢定方面的專家。曾任中國藥品生物制品檢定所常務副所長、國家食品藥物監(jiān)督管理局藥品評價中心主任等職務。從事藥品質量分析研究30年中，共獲國家科技進步獎3項，省部級科技進步獎8項。擔任中國藥學會理事、中國藥學會抗生素分科學會副主任委員、中國藥典委員會抗生素專業(yè)委員會主任委員、國家藥品監(jiān)督管理局藥品審評專家、農業(yè)部獸用藥品審評委員、WHO西太區(qū)耐藥性監(jiān)測網監(jiān)測員、世界衛(wèi)生組織國際藥典和藥品專家委員會委員。同時，兼任《中國抗生素雜志》、《藥物分析雜志》、《中國藥事》、《中國新藥雜志》、《中國抗感染化療雜志》、《中國臨床藥理學雜志》等雜志編委。

圖書目錄

Rapid Analysis of Chemical Drugs Using the Near-infrared Spectroscopic Technology

Chapter 1　NIR Spectrometer　/ 7
Classification and Characteristics of NIR Spectrometer　/ 7
Key Performance Indicators of NIR Spectroscopic Instrument　/ 11
Acquisition of NIR Spectrum　/ 16
NIR Spectrometer in Mobile lab　/ 17

Chapter 2　Introduction Near-infrared Analysis Methods　/ 20
Spectral Data Preprocessing Methods　/ 21
Qualitative Analysis Method 　/ 25
Cluster Analysis　/ 31
Quantitative Analysis　/ 35
Conformity Test Analysis　/ 45
Correlation Coefficient Analysis　/ 49
Methods of Model Transfer 　/ 52

Chapter 3　Application of NIR Methods in Drug Analysis　/ 58
Analysis of Antibiotics Using NIR Methods　/ 59
CASE STUDY 1　 Establishment of Qualitative NIR Models for the Analysis of Cephalosporin Injection Powder Products　/ 61
CASE STUDY 2　 Rapid Determination of Cefuroxime Sodium Content Using NIR Analysis　/ 66
CASE STUDY 3　 Construction of a Universal NIR Model for Quantitative Analysis of Cefradine Capsules　/ 73
CASE STUDY 4　 Development of a Universal NIR Model for Quantitative Analysis of Phenoxymethylpenicillin Potassium Tablets　/ 79
CASE STUDY 5　 Universal NIR Models for the Quantitative Analysis of Ceftriaxone and Water Contents in Ceftriaxone Sodium Injection Products　/ 85
Analysis of Chemical Drugs Using NIR Methods　/ 96
CASE STUDY 6　 Construction of a Quantitative Model for Simvastatin Tablets　/ 98
CASE STUDY 7　 NIR Models for Quantitative Analysis of Aminosalicylate and Water Contents in Sodium Aminosalicylate Injections　/ 102
CASE STUDY 8　 Rapid Analysis of Potassium Dehydroandrographolide Succinate Injection Using NIRDRS 　/ 108
CASE STUDY 9　 NIR Identification and Analysis of Compound Paracetamol and Amantadine Hydrochloride Tablets 　/ 115
Application of NIR Spectroscopy in the Analysis of Traditional Chinese Medicines (TCM)　/ 120
CASE STUDY 10　 Establishment of a Qualitative NIR Model for Cortex Magnoliae officinalis　/ 122
CASE STUDY 11　 Analysis of Water Content in Liuwei Dihuang Pills Using NIR Spectroscopy　/ 129
CASE STUDY 12　 Qualitative Analysis of Different Brands of Jianwei Xiaoshi Tablets Using NIR Spectroscopy　/ 131
CASE STUDY 13　 Identification of Decoction Pieces of Common Yam Rhizome by NIR Method 　/ 133
NIR Analysis of Illegal Additives in Medicinal Products　/ 143
CASE STUDY 14　 Illegal Addition of Sildenafil Citrate into Chinese Patent Medicine　/ 144
CASE STUDY 15　 Norfloxacin Addition in Lopermide Hydrochloride Capsules　/ 146
CASE STUDY 16　 NIR Correlation Analysis of Illegal Added Phenformin Hydrochloride in Chinese Patent Medicines　/ 147
NIR Analysis of Liquid Formulations 　/ 152
CASE STUDY 17　 Construction NIR Quantitative Model for Glucose Injection 　/ 154
Applications of NIR Methods on Mobile Laboratory Vehicles 　/ 161
CASE STUDY 18　 The Establishment and Application of Blank Models Used for Spectra Comparison 　/ 164
CASE STUDY 19　 Establishment and Application of the Characteristic Spectral Range Screening Method 　/ 171

Chapter 4　Prospect of NIR Analysis Methods　/ 184
Development Prospect of NIR Analytical Instruments 　/ 185
Prospect of the Application of NIR Analysis Method 　/ 186
Prospect of NIR Analysis Methods being Listed in the National Drug Standards of Different Countries　/ 190
References　/ 192

Rapid HPLC Forensic Analysis of Chemical Medicines

Chapter 5　 Basic Principles and Methods for Rapid HPLC Analysis　/ 202
Identification 　/ 202
Content Determination　/ 202
Establishment and Validation of the Rapid HPLC Forensic Method　/ 203

Chapter 6　Applications of Rapid HPLC Analysis　/ 220
β-lactam Antibiotics　/ 221
Macrolide Antibiotics　/ 257
Quinolone Antibiotics 　/ 276
Adrenocortical Hormone Drugs　/ 290
Sex Hormone Drugs　/ 306
Antidiabetic Drugs　/ 318
Calcium Channel Blockers　/ 332

Chapter 7　Progress of Rapid HPLC Analysis　/ 347
Establishment of Reference Database and Applications　/ 347
Rapid Analysis by LC-MS　/ 349

References　/ 353